HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block

Pharmacologic inhibition of LSD1 induces molecular and morphologic differentiation of blast cells in acute myeloid leukemia (AML) patients harboring MLL gene translocations. In addition to its demethylase activity, LSD1 has a critical scaffolding function at genomic sites occupied by the SNAG domain...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Maiques-Diaz, Alba, Nicosia, Luciano, Basma, Naseer J., Romero-Camarero, Isabel, Camera, Francesco, Spencer, Gary J., Amaral, Fabio M. R., Simeoni, Fabrizio, Wingelhofer, Bettina, Williamson, Andrew J. K., Pierce, Andrew, Whetton, Anthony D., Somervaille, Tim C. P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2022
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613766/
https://ncbi.nlm.nih.gov/pubmed/36171271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-022-02471-y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados