Integrated DNA and RNA Sequencing Reveals Drivers of Endocrine Resistance in Estrogen Receptor–Positive Breast Cancer

PURPOSE: Endocrine therapy resistance (ETR) remains the greatest challenge in treating patients with hormone receptor–positive breast cancer. We set out to identify molecular mechanisms underlying ETR through in-depth genomic analysis of breast tumors. EXPERIMENTAL DESIGN: We collected pre-treatment...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Xia, Youli, He, Xiaping, Renshaw, Lorna, Martinez-Perez, Carlos, Kay, Charlene, Gray, Mark, Meehan, James, Parker, Joel S., Perou, Charles M., Carey, Lisa A., Dixon, J. Michael, Turnbull, Arran
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research 2022
Assuntos:
Translational Cancer Mechanisms and Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613305/
https://ncbi.nlm.nih.gov/pubmed/35653148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-21-3189
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