Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms

The implications of stem cell heterogeneity for disease pathogenesis and therapy are poorly defined. JAK2V617F(+) myeloproliferative neoplasms (MPNs), harboring the same mutation in hematopoietic stem cells (HSCs), display diverse phenotypes, including polycythemia vera (PV), essential thrombocythem...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Tong, Jingyuan, Sun, Ting, Ma, Shihui, Zhao, Yanhong, Ju, Mankai, Gao, Yuchen, Zhu, Ping, Tan, Puwen, Fu, Rongfeng, Zhang, Anqi, Wang, Ding, Wang, Di, Xiao, Zhijian, Zhou, Jiaxi, Yang, Renchi, Loughran, Stephen J., Li, Juan, Green, Anthony R., Bresnick, Emery H., Wang, Dong, Cheng, Tao, Zhang, Lei, Shi, Lihong
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613297/
https://ncbi.nlm.nih.gov/pubmed/33798424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2021.02.026
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