Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response

Cell fate decisions during early B cell activation determine the outcome of responses to pathogens and vaccines. We examined the early B cell response to T-dependent antigen in mice by single-cell RNA sequencing. Early after immunization, a homogeneous population of activated precursors (APs) gave r...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Glaros, Vassilis, Rauschmeier, René, Artemov, Artem V., Reinhardt, Annika, Ols, Sebastian, Emmanouilidi, Aikaterini, Gustafsson, Charlotte, You, Yuanyuan, Mirabello, Claudio, Björklund, Åsa K., Perez, Laurent, King, Neil P., Månsson, Robert, Angeletti, Davide, Loré, Karin, Adameyko, Igor, Busslinger, Meinrad, Kreslavsky, Taras
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612941/
https://ncbi.nlm.nih.gov/pubmed/34525339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.08.017
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