The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle

SARS-CoV-2, like other coronaviruses, builds a membrane-bound replication organelle (RO) to enable RNA replication(1). The SARS-CoV-2 RO is composed of double membrane vesicles (DMVs) tethered to the endoplasmic reticulum (ER) by thin membrane connectors(2), but the viral proteins and the host facto...

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Udgivet i:Nature
Main Authors: Ricciardi, Simona, Guarino, Andrea Maria, Giaquinto, Laura, Polishchuk, Elena V., Santoro, Michele, Di Tullio, Giuseppe, Wilson, Cathal, Panariello, Francesco, Soares, Vinicius C., Dias, Suelen S.G., Santos, Julia C., Souza, Thiago M.L., Fusco, Giovanna, Viscardi, Maurizio, Brandi, Sergio, Bozza, Patrícia T., Polishchuk, Roman S., Venditti, Rossella, De Matteis, Maria Antonietta
Format: Artigo
Sprog:Inglês
Udgivet: 2022
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612910/
https://ncbi.nlm.nih.gov/pubmed/35551511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-022-04835-6
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