Labile Photo‐Induced Free Radical in α‐Ketoglutaric Acid: a Universal Endogenous Polarizing Agent for In Vivo Hyperpolarized (13)C Magnetic Resonance

Hyperpolarized (HP) (13)C magnetic resonance enables non‐invasive probing of metabolism in vivo. To date, only (13)C‐molecules hyperpolarized with persistent trityl radicals have been injected in humans. We show here that the free radical photo‐induced in alpha‐ketoglutaric acid (α‐KG) can be used t...

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Detalles Bibliográficos
Publicado en:Angew Chem Int Ed Engl
Main Authors: Gaunt, Adam P., Lewis, Jennifer S., Hesse, Friederike, Cheng, Tian, Marco‐Rius, Irene, Brindle, Kevin M., Comment, Arnaud
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2021
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612908/
https://ncbi.nlm.nih.gov/pubmed/34679201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202112982
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