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Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials

Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moeity of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to, therapeutic efficacy against...

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Pubblicato in:Br J Clin Pharmacol
Autori principali: White, Nicholas J, Watson, James A, Baird, J Kevin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2022
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612727/
https://ncbi.nlm.nih.gov/pubmed/34997616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.15219
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