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Structure and mechanism of the methyltransferase ribozyme MTR1

RNA-catalysed RNA methylation was recently shown to be part of the catalytic repertoire of ribozymes. The methyltransferase ribozyme MTR1 catalyses the site-specific synthesis of 1-methyladenosine (m(1)A) in RNA, using O(6)-methylguanine (m(6)G) as methyl group donor. Here we report the crystal stru...

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Publicat a:Nat Chem Biol
Autors principals: Scheitl, Carolin P.M., Mieczkowski, Mateusz, Schindelin, Hermann, Höbartner, Claudia
Format: Artigo
Idioma:Inglês
Publicat: 2022
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612680/
https://ncbi.nlm.nih.gov/pubmed/35301481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-022-00976-x
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