Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy

Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and overall association with favorable therapeutic responses remain incompletely understood. Here we demonstrate that an oncogenic mutant form of NPM1 (N...

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Publicat a:Cancer Discov
Autors principals: Wu, Hsin-Chieh, Rérolle, Domitille, Berthier, Caroline, Hleihel, Rita, Sakamoto, Takashi, Quentin, Samuel, Benhenda, Shirine, Morganti, Claudia, Wu, Chengchen, Conte, Lidio, Rimsky, Sylvie, Sebert, Marie, Clappier, Emmanuelle, Souquere, Sylvie, Gachet, Stéphanie, Soulier, Jean, Durand, Sylvère, Trowbridge, Jennifer J., Bénit, Paule, Rustin, Pierre, El Hajj, Hiba, Raffoux, Emmanuel, Ades, Lionel, Itzykson, Raphael, Dombret, Hervé, Fenaux, Pierre, Espeli, Olivier, Kroemer, Guido, Brunetti, Lorenzo, Mak, Tak W., Lallemand-Breitenbach, Valérie, Bazarbachi, Ali, Falini, Brunangelo, Ito, Keisuke, Martelli, Maria Paola, de Thé, Hugues
Format: Artigo
Idioma:Inglês
Publicat: American Association for Cancer Research 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612574/
https://ncbi.nlm.nih.gov/pubmed/34301789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-21-0177
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