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Pharmacodynamic Biomarkers for Quantifying the Mycobacterial Effect of High Doses of Rifampin in Patients with Rifampin-susceptible Pulmonary Tuberculosis

BACKGROUND: Suboptimal drug exposure in patients with drug-susceptible tuberculosis (DS-TB) can drive treatment failure. Pharmacodynamics (PD) biomarkers such as the plasma TB drug-activity (TDA) assay may guide dose finding studies and predict microbiological outcomes differently than conventional...

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Detalhes bibliográficos
Publicado no:Int J Mycobacteriol
Main Authors: Said, Bibie N, Heysell, Scott K, Yimer, Getnet, Aarnoutse, Rob E., Kibiki, Gibson S, Mpagama, Stellah, Mbelele, Peter M
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612567/
https://ncbi.nlm.nih.gov/pubmed/34916467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/ijmy.ijmy_178_21
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