Polygenic risk scores for prediction of breast cancer risk in Asian populations

PURPOSE: Non-European populations are under-represented in genetics studies, hindering clinical implementation of breast cancer polygenic risk scores (PRSs). We aimed to develop PRSs using the largest available studies of Asian ancestry and to assess the transferability of PRS across ethnic subgroup...

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Publicado en:Genet Med
Autores principales: Ho, Weang-Kee, Tai, Mei-Chee, Dennis, Joe, Shu, Xiang, Li, Jingmei, Ho, Peh Joo, Millwood, Iona Y., Lin, Kuang, Jee, Yon-Ho, Lee, Su-Hyun, Mavaddat, Nasim, Bolla, Manjeet K., Wang, Qin, Michailidou, Kyriaki, Long, Jirong, Wijaya, Eldarina Azfar, Hassan, Tiara, Rahmat, Kartini, Tan, Veronique Kiak Mien, Tan, Benita Kiat Tee, Tan, Su Ming, Tan, Ern Yu, Lim, Swee Ho, Gao, Yu-Tang, Zheng, Ying, Kang, Daehee, Choi, Ji-Yeob, Han, Wonshik, Lee, Han-Byoel, Kubo, Michiki, Okada, Yukinori, Namba, Shinichi, Park, Sue K., Kim, Sung-Won, Shen, Chen-Yang, Wu, Pei-Ei, Park, Boyoung, Muir, Kenneth R., Lophatananon, Artitaya, Wu, Anna H., Tseng, Chiu-Chen, Matsuo, Keitaro, Ito, Hidemi, Kwong, Ava, Chan, Tsun L., John, Esther M., Kurian, Allison W., Iwasaki, Motoki, Yamaji, Taiki, Kweon, Sun-Seog, Aronson, Kristan J., Murphy, Rachel A., Koh, Woon-Puay, Khor, Chiea-Chuen, Yuan, Jian-Min, Dorajoo, Rajkumar, Walters, Robin G., Chen, Zhengming, Li, Liming, Lv, Jun, Jung, Keum-Ji, Kraft, Peter, Pharoah, Paul D.B., Dunning, Alison M., Simard, Jacques, Shu, Xiao-Ou, Yip, Cheng-Har, Taib, Nur Aishah Mohd, Antoniou, Antonis C., Zheng, Wei, Hartman, Mikael, Easton, Douglas F., Teo, Soo-Hwang
Formato: Artigo
Lenguaje:Inglês
Publicado: 2022
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612481/
https://ncbi.nlm.nih.gov/pubmed/34906514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gim.2021.11.008
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