Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis

OBJECTIVES: The HLA-shared epitope-alleles (HLA-SE) and smoking are the most prominent genetic and environmental risk factors for rheumatoid arthritis (RA). However, at which pre-arthritis stage (asymptomatic/symptomatic) they exert their effect is unknown. We aimed to determine whether HLA-SE and s...

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Publicat a:Ann Rheum Dis
Autors principals: Wouters, Fenne, Maurits, Marc P., van Boheemen, Laurette, Verstappen, Marloes, Mankia, Kulveer, Matthijssen, Xanthe M.E., Dorjée, Annemarie L., Emery, Paul, Knevel, Rachel, van Schaardenburg, Dirkjan, Toes, René E.M., van der Helm-van Mil, Annette H.M.
Format: Artigo
Idioma:Inglês
Publicat: 2022
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612192/
https://ncbi.nlm.nih.gov/pubmed/34285049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2021-220546
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