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Bottom-up fabrication of a proteasome-nanopore that unravels and processes single proteins

The precise assembly and engineering of molecular machines capable of handling biomolecules play crucial roles in most single-molecule methods. In this work, using components from all three domains of life, we fabricate an integrated multi-protein complex that controls the unfolding and threading of...

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Bibliographic Details
Published in:Nat Chem
Main Authors: Zhang, Shengli, Huang, Gang, Versloot, Roderick, Bruininks, Bart Marlon Herwig, Telles de Souza, Paulo Cesar, Marrink, Siewert-Jan, Maglia, Giovanni
Format: Artigo
Language:Inglês
Published: 2021
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612055/
https://ncbi.nlm.nih.gov/pubmed/34795436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-021-00824-w
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