Anti-inflammatory drugs remodel the tumor immune environment to enhance immune checkpoint blockade efficacy

Identifying strategies to improve the efficacy of immune checkpoint blockade (ICB) remains a major clinical need. Here, we show that therapeutically targeting the COX-2/PGE(2)/EP2-4 pathway with widely used non-steroidal and steroidal anti-inflammatory drugs synergized with ICB in mouse cancer model...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Pelly, Victoria S., Moeini, Agrin, Roelofsen, Lisanne M., Bonavita, Eduardo, Bell, Charlotte R., Hutton, Colin, Blanco-Gomez, Adrian, Banyard, Antonia, Bromley, Christian P., Flanagan, Eimear, Chiang, Shih-Chieh, Jørgensen, Claus, Schumacher, Ton N., Thommen, Daniela S., Zelenay, Santiago
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611767/
https://ncbi.nlm.nih.gov/pubmed/34031121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-1815
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