Organoid modeling of Zika and Herpes Simplex virus 1 infections reveals virus-specific responses leading to microcephaly

Viral infections in early pregnancy are a major cause of microcephaly. However, how distinct viruses impair human brain development remains poorly understood. Here we use human brain organoids to study the mechanisms underlying microcephaly caused by Zika Virus (ZIKV) and Herpes Simplex Virus (HSV-1...

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Publicado en:Cell Stem Cell
Autores principales: Krenn, Veronica, Bosone, Camilla, Burkard, Thomas Rainer, Spanier, Julia, Kalinke, Ulrich, Calistri, Arianna, Salata, Cristiano, Christoff, Raissa Rilo, Garcez, Patricia Pestana, Mirazimi, Ali, Knoblich, Jürgen Arthur
Formato: Artigo
Lenguaje:Inglês
Publicado: 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611471/
https://ncbi.nlm.nih.gov/pubmed/33838105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2021.03.004
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