Cortical grey matter sodium accumulation is associated with disability and secondary progressive disease course in relapse-onset multiple sclerosis

OBJECTIVE: Sodium ((23)Na)-MRI is an emerging imaging technique to investigate in vivo changes in tissue viability, reflecting neuroaxonal integrity and metabolism. Using an optimised (23)Na-MRI protocol with smaller voxel sizes and improved tissue contrast, we wanted to investigate whether brain to...

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Pubblicato in:J Neurol Neurosurg Psychiatry
Autori principali: Brownlee, Wallace J, Solanky, Bhavana, Prados, Ferran, Yiannakas, Marios, Da Mota, Patricia, Riemer, Frank, cardoso, Manuel Jorge, Ourselin, Sebastian, Golay, Xavier, Wheeler-Kingshott, Claudia Gandini, Ciccarelli, Olga
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611428/
https://ncbi.nlm.nih.gov/pubmed/30948625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2018-319634
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