Targeting herpes simplex virus with CRISPR-Cas9 cures herpetic stromal keratitis in mice

Herpes simplex virus type 1 (HSV-1) is a leading cause of infectious blindness. Current treatments for HSV-1 do not eliminate the virus from the site of infection or latent reservoirs in the trigeminal ganglia. Here, we target HSV-1 genomes directly using mRNA-carrying lentiviral particles that simu...

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Detaylı Bibliyografya
Yayımlandı:Nat Biotechnol
Asıl Yazarlar: Yin, Di, Ling, Sikai, Wang, Dawei, Dai, Yao, Jiang, Hao, Zhou, Xujiao, Paludan, Soren R., Hong, Jiaxu, Cai, Yujia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611178/
https://ncbi.nlm.nih.gov/pubmed/33432198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-00781-8
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