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Targeting herpes simplex virus with CRISPR-Cas9 cures herpetic stromal keratitis in mice
Herpes simplex virus type 1 (HSV-1) is a leading cause of infectious blindness. Current treatments for HSV-1 do not eliminate the virus from the site of infection or latent reservoirs in the trigeminal ganglia. Here, we target HSV-1 genomes directly using mRNA-carrying lentiviral particles that simu...
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| Pubblicato in: | Nat Biotechnol |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7611178/ https://ncbi.nlm.nih.gov/pubmed/33432198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-00781-8 |
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