Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism

Complexes containing a pair of SMC family proteins are fundamental for the 3D organization of genomes in all domains of life. The eukaryotic SMC complexes cohesin and condensin are thought to fold, respectively, interphase and mitotic chromosomes into large loop domains, although the underlying mole...

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Bibliografske podrobnosti
izdano v:Nat Struct Mol Biol
Main Authors: Lee, Byung-Gil, Merkel, Fabian, Allegretti, Matteo, Hassler, Markus, Cawood, Christopher, Lecomte, Léa, O’Reilly, Francis J., Sinn, Ludwig R., Gutierrez-Escribano, Pilar, Kschonsak, Marc, Bravo, Sol, Nakane, Takanori, Rappsilber, Juri, Aragon, Luis, Beck, Martin, Löwe, Jan, Haering, Christian H.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610691/
https://ncbi.nlm.nih.gov/pubmed/32661420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0457-x
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