SMN-primed ribosomes modulate the translation of transcripts related to Spinal Muscular Atrophy

The contribution of ribosome heterogeneity and ribosome-associated proteins to the molecular control of proteomes in health and disease remains enigmatic. We demonstrate that Survival Motor Neuron (SMN) protein, loss of which causes the neuromuscular disease spinal muscular atrophy (SMA), binds to r...

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Published in:Nat Cell Biol
Main Authors: Lauria, Fabio, Bernabò, Paola, Tebaldi, Toma, Groen, Ewout Joan Nicolaas, Perenthaler, Elena, Maniscalco, Federica, Rossi, Annalisa, Donzel, Deborah, Clamer, Massimiliano, Marchioretto, Marta, Omersa, Neža, Orri, Julia, Serra, Mauro Dalla, Anderluh, Gregor, Quattrone, Alessandro, Inga, Alberto, Gillingwater, Thomas Henry, Viero, Gabriella
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610479/
https://ncbi.nlm.nih.gov/pubmed/32958857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-00577-7
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