A dual constriction biological nanopore resolves homonucleotide sequences with high fidelity

Single-molecule long-read DNA sequencing with biological nanopores is fast and high-throughput but suffers reduced accuracy in homonucleotide stretches. We now combine the CsgG nanopore with the 35-residue N-terminal region of its extracellular interaction partner CsgF to produce a dual-constriction...

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Publicat a:Nat Biotechnol
Autors principals: Van der Verren, Sander E., Van Gerven, Nani, Jonckheere, Wim, Hambley, Richard, Singh, Pratik, Kilgour, John, Jordan, Michael, Wallace, E. Jayne, Jayasinghe, Lakmal, Remaut, Han
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610451/
https://ncbi.nlm.nih.gov/pubmed/32632300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-0570-8
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