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Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations
LRRK2 is a kinase expressed in striatal spiny projection neurons (SPNs), cells which lose dopaminergic input in Parkinson’s disease (PD). R1441C and G2019S are the most common pathogenic mutations of LRRK2. How these mutations alter the structure and function of individual synapses on direct and ind...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7609054/ https://ncbi.nlm.nih.gov/pubmed/33006315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58997 |
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