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Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for…
ERK5 is a protein kinase that also contains a nuclear localisation signal and a transcriptional transactivation domain. Inhibition of ERK5 has therapeutic potential in cancer and inflammation and this has prompted the development of ERK5 kinase inhibitors (ERK5i). However, few ERK5i programmes have...
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| Yayımlandı: | Biochem Soc Trans |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Portland Press Ltd.
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7609025/ https://ncbi.nlm.nih.gov/pubmed/32915196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20190338 |
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