Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio

Externally deposited eggs begin development with an immense cytoplasm and a single overwhelmed nucleus. Rapid mitotic cycles restore normality as the ratio of nuclei to cytoplasm (N/C) increases. A threshold N/C has been widely proposed to activate zygotic genome transcription and onset of morphogen...

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Bibliographic Details
Published in:PLoS Biol
Main Authors: Strong, Isaac J. T., Lei, Xiaoyun, Chen, Fang, Yuan, Kai, O’Farrell, Patrick H.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608951/
https://ncbi.nlm.nih.gov/pubmed/33090988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000891
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