LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer

Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-resistant breast cancer cells. Mechanistically, DIL...

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Publié dans:Nat Commun
Auteurs principaux: Shi, Qianfeng, Li, Yudong, Li, Shunying, Jin, Liang, Lai, Hongna, Wu, Yanqing, Cai, Zijie, Zhu, Mengdi, Li, Qian, Li, Ying, Wang, Jingru, Liu, Yujie, Wu, Zongqi, Song, Erwei, Liu, Qiang
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608661/
https://ncbi.nlm.nih.gov/pubmed/33139730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19349-w
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