The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation

To determine the respective contribution of the LAT transmembrane adaptor and CD5 and CD6 transmembrane receptors to early TCR signal propagation, diversification, and termination, we describe a CRISPR/Cas9–based platform that uses primary mouse T cells and permits establishment of the composition o...

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Udgivet i:J Exp Med
Main Authors: Mori, Daiki, Grégoire, Claude, Voisinne, Guillaume, Celis-Gutierrez, Javier, Aussel, Rudy, Girard, Laura, Camus, Mylène, Marcellin, Marlène, Argenty, Jérémy, Burlet-Schiltz, Odile, Fiore, Frédéric, Gonzalez de Peredo, Anne, Malissen, Marie, Roncagalli, Romain, Malissen, Bernard
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608068/
https://ncbi.nlm.nih.gov/pubmed/33125054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201011
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