Aging suppresses sphingosine-1-phosphate (S1P) chaperone ApoM in circulation resulting in maladaptive organ repair

Here we show that the liver-derived apolipoprotein M (ApoM) protects the lung and kidney from pro-fibrotic insults and that this circulating factor is attenuated in aged mice. Aged mouse hepatocytes exhibit transcriptional suppression of ApoM. This leads to reduced sphingosine-1-phosphate (S1P) sign...

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Udgivet i:Dev Cell
Main Authors: Ding, Bi-Sen, Yang, Dawei, Swendeman, Steve L., Christoffersen, Christina, Nielsen, Lars Bo, Friedman, Scott L., Powell, Charles A., Hla, Timothy, Cao, Zhongwei
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7607448/
https://ncbi.nlm.nih.gov/pubmed/32544390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.05.024
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