Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia

Enzymes that cleave ATP to activate carboxylic acids play essential roles in primary and secondary metabolism in all domains of life. Class I adenylate-forming enzymes share a conserved structural fold but act on a wide range of substrates to catalyze reactions involved in bioluminescence, nonriboso...

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Publicado en:J Biol Chem
Autores principales: Robinson, Serina L., Terlouw, Barbara R., Smith, Megan D., Pidot, Sacha J., Stinear, Timothy P., Medema, Marnix H., Wackett, Lawrence P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Computational Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606675/
https://ncbi.nlm.nih.gov/pubmed/32826316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013528
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