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Human ribosomal G-quadruplexes regulate heme bioavailability

The in vitro formation of stable G-quadruplexes (G4s) in human rRNA was recently reported. However, their formation in cells and their cellular roles were not resolved. Here, by taking a chemical biology approach that integrates results from immunofluorescence, G4 ligands, heme-affinity reagents, an...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mestre-Fos, Santi, Ito, Chieri, Moore, Courtney M., Reddi, Amit R., Williams, Loren Dean
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606673/
https://ncbi.nlm.nih.gov/pubmed/32817343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014332
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