Derivation and Validation of Genome Wide Polygenic Score for Urinary Tract Stone Diagnosis

Urinary tract stones have high heritability indicating a strong genetic component. However, genome wide association studies (GWAS) have uncovered only a few genome wide significant single nucleotide polymorphisms (SNPs). Polygenic risk scores (PRS) sum cumulative effect of many SNPs and shed light o...

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Detalhes bibliográficos
Publicado no:Kidney Int
Main Authors: Paranjpe, Ishan, Tsao, Noah, Judy, Renae, Paranjpe, Manish, Chaudhary, Kumardeep, Klein, Derek, Forrest, Iain, O’Hagan, Ross, Kapoor, Arjun, Pfail, John, Jaladanki, Suraj, Chaudhry, Fayzan, Vaid, Akhil, Duy, Phan Q., He, John Cijiang, Glicksberg, Benjamin S, Coca, Steven G, Gupta, Mantu, Do, Ron, Damrauer, Scott M., Nadkarni, Girish N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606592/
https://ncbi.nlm.nih.gov/pubmed/32540406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2020.04.055
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