Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms

Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific phospholipase A(2) inhibitor), marimastat (broad sp...

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Publicado en:Acta Pharm Sin B
Autores principales: Xie, Chunfang, Slagboom, Julien, Albulescu, Laura-Oana, Somsen, Govert W., Vonk, Freek J., Casewell, Nicholas R., Kool, Jeroen
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606088/
https://ncbi.nlm.nih.gov/pubmed/33163338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.09.005
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