Loss of the RNA trimethylguanosine cap is compatible with nuclear accumulation of spliceosomal snRNAs but not pre-mRNA splicing or snRNA processing during animal development

The 2,2,7-trimethylguanosine (TMG) cap is one of the first identified modifications on eukaryotic RNAs. TMG, synthesized by the conserved Tgs1 enzyme, is abundantly present on snRNAs essential for pre-mRNA splicing. Results from ex vivo experiments in vertebrate cells suggested that TMG ensures nucl...

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Dettagli Bibliografici
Pubblicato in:PLoS Genet
Autori principali: Cheng, Lin, Zhang, Yu, Zhang, Yi, Chen, Tao, Xu, Yong-Zhen, Rong, Yikang S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605716/
https://ncbi.nlm.nih.gov/pubmed/33085660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009098
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