Tranilast Inhibits Pulmonary Fibrosis by Suppressing TGFβ/SMAD2 Pathway

PURPOSE: Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of extracellular matrix (ECM) protein in the lungs. Transforming growth factor (TGF) β-induced ECM protein synthesis contributes to the development of IPF. Tranilast, an anti-allergy drug, suppresses TGFβ expression an...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Kato, Motoyasu, Takahashi, Fumiyuki, Sato, Tadashi, Mitsuishi, Yoichiro, Tajima, Ken, Ihara, Hiroaki, Nurwidya, Fariz, Baskoro, Hario, Murakami, Akiko, Kobayashi, Isao, Hidayat, Moulid, Shimada, Naoko, Sasaki, Shinichi, Mineki, Reiko, Fujimura, Tsutomu, Kumasaka, Toshio, Niwa, Shin-ichiro, Takahashi, Kazuhisa
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605600/
https://ncbi.nlm.nih.gov/pubmed/33149556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S264715
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