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An Etiological Foxp2 Mutation Impairs Neuronal Gain in Layer VI Cortico-Thalamic Cells through Increased GABA(B)/GIRK Signaling
A rare mutation affecting the Forkhead-box protein P2 (FOXP2) transcription factor causes a severe monogenic speech and language disorder. Mice carrying an identical point mutation to that observed in affected patients (Foxp2(+/R552H) mice) display motor deficits and impaired synaptic plasticity in...
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| Publicado no: | J Neurosci |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7605419/ https://ncbi.nlm.nih.gov/pubmed/33020214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2615-19.2020 |
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