Aging-Exacerbated Acute Axon and Myelin Injury Is Associated with Microglia-Derived Reactive Oxygen Species and Is Alleviated by the Generic Medication Indapamide

Age is a critical risk factor for many neurologic conditions, including progressive multiple sclerosis. Yet the mechanisms underlying the relationship are unknown. Using lysolecithin-induced demyelinating injury to the mouse spinal cord, we characterized the acute lesion and investigated the mechani...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Michaels, Nathan J., Lemmon, Kennedy, Plemel, Jason R., Jensen, Samuel K., Mishra, Manoj K., Brown, Dennis, Rawji, Khalil S., Koch, Marcus, Yong, V. Wee
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605417/
https://ncbi.nlm.nih.gov/pubmed/33060175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1098-20.2020
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