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V(DD)J recombination is an important and evolutionarily conserved mechanism for generating antibodies with unusually long CDR3s

The V(DD)J recombination is currently viewed as an aberrant and inconsequential variant of the canonical V(D)J recombination. Moreover, since the classical 12/23 rule for the V(D)J recombination fails to explain the V(DD)J recombination, the molecular mechanism of tandem D-D fusions has remained unk...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Safonova, Yana, Pevzner, Pavel A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605257/
https://ncbi.nlm.nih.gov/pubmed/32948615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.259598.119
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