Type I Collagen Signaling Regulates Opposing Fibrotic Pathways through α(2)β(1) Integrin

Fibrosis is characterized by fibroblast activation, leading to matrix remodeling culminating in a stiff, type I collagen–rich fibrotic matrix. Alveolar epithelial cell (AEC) apoptosis is also a major feature of fibrogenesis, and AEC apoptosis is sufficient to initiate a robust lung fibrotic response...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Agarwal, Manisha, Goheen, Mitchell, Jia, Shijing, Ling, Song, White, Eric S., Kim, Kevin K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605165/
https://ncbi.nlm.nih.gov/pubmed/32692932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2020-0150OC
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