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Type I Collagen Signaling Regulates Opposing Fibrotic Pathways through α(2)β(1) Integrin
Fibrosis is characterized by fibroblast activation, leading to matrix remodeling culminating in a stiff, type I collagen–rich fibrotic matrix. Alveolar epithelial cell (AEC) apoptosis is also a major feature of fibrogenesis, and AEC apoptosis is sufficient to initiate a robust lung fibrotic response...
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| Veröffentlicht in: | Am J Respir Cell Mol Biol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Thoracic Society
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7605165/ https://ncbi.nlm.nih.gov/pubmed/32692932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2020-0150OC |
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