Increasing Sphingolipid Synthesis Alleviates Airway Hyperreactivity

Impaired sphingolipid synthesis is linked genetically to childhood asthma and functionally to airway hyperreactivity (AHR). The objective was to investigate whether sphingolipid synthesis could be a target for asthma therapeutics. The effects of GlyH-101 and fenretinide via modulation of de novo sph...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Respir Cell Mol Biol
Prif Awduron: Heras, Andrea F., Veerappan, Arul, Silver, Randi B., Emala, Charles W., Worgall, Tilla S., Perez-Zoghbi, Jose, Worgall, Stefan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Thoracic Society 2020
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605160/
https://ncbi.nlm.nih.gov/pubmed/32706610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2020-0194OC
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