MAIT cells are imprinted by the microbiota in early life and promote tissue repair

How early-life colonization and subsequent exposure to the microbiota impact long-term tissue immunity remains poorly understood. Here we show that the development of mucosal-associated invariant T (MAIT) cells relies on a specific temporal window, after which MAIT cell development is permanently im...

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Опубликовано в: :Science
Главные авторы: Constantinides, Michael G., Link, Verena M., Tamoutounour, Samira, Wong, Andrea C., Perez-Chaparro, P. Juliana, Han, Seong-Ji, Chen, Y. Erin, Li, Kelin, Farhat, Sepideh, Weckel, Antonin, Krishnamurthy, Siddharth R., Vujkovic-Cvijin, Ivan, Linehan, Jonathan L., Bouladoux, Nicolas, Merrill, E. Dean, Roy, Sobhan, Cua, Daniel J., Adams, Erin J., Bhandoola, Avinash, Scharschmidt, Tiffany C., Aubé, Jeffrey, Fischbach, Michael A., Belkaid, Yasmine
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7603427/
https://ncbi.nlm.nih.gov/pubmed/31649166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax6624
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