Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

SIMPLE SUMMARY: Drugs that sensitise tumours to chemotherapy by enhancing cell death signalling are of significant clinical interest. However, it is challenging to determine which colorectal cancer patients may benefit from such sensitisers. The ability to predict this would be advantageous. Here we...

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Publicat a:Cancers (Basel)
Autors principals: O’Farrell, Alice C., Jarzabek, Monika A., Lindner, Andreas U., Carberry, Steven, Conroy, Emer, Miller, Ian S., Connor, Kate, Shiels, Liam, Zanella, Eugenia R., Lucantoni, Federico, Lafferty, Adam, White, Kieron, Meyer Villamandos, Mariangela, Dicker, Patrick, Gallagher, William M., Keek, Simon A., Sanduleanu, Sebastian, Lambin, Philippe, Woodruff, Henry C., Bertotti, Andrea, Trusolino, Livio, Byrne, Annette T., Prehn, Jochen H. M.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7602510/
https://ncbi.nlm.nih.gov/pubmed/33066609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12102978
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