Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

SIMPLE SUMMARY: Drugs that sensitise tumours to chemotherapy by enhancing cell death signalling are of significant clinical interest. However, it is challenging to determine which colorectal cancer patients may benefit from such sensitisers. The ability to predict this would be advantageous. Here we...

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Bibliografiska uppgifter
I publikationen:Cancers (Basel)
Huvudupphovsmän: O’Farrell, Alice C., Jarzabek, Monika A., Lindner, Andreas U., Carberry, Steven, Conroy, Emer, Miller, Ian S., Connor, Kate, Shiels, Liam, Zanella, Eugenia R., Lucantoni, Federico, Lafferty, Adam, White, Kieron, Meyer Villamandos, Mariangela, Dicker, Patrick, Gallagher, William M., Keek, Simon A., Sanduleanu, Sebastian, Lambin, Philippe, Woodruff, Henry C., Bertotti, Andrea, Trusolino, Livio, Byrne, Annette T., Prehn, Jochen H. M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7602510/
https://ncbi.nlm.nih.gov/pubmed/33066609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12102978
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