FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer

SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy that is projected to become the leading cause of cancer death by 2050. Fibroblast growth factor receptor 4 (FGFR4) is a transmembrane receptor that is overexpressed in half of PDACs. We determined that its expression in P...

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Publicado en:Cancers (Basel)
Autores principales: Sasaki, Norihiko, Gomi, Fujiya, Yoshimura, Hisashi, Yamamoto, Masami, Matsuda, Yoko, Michishita, Masaki, Hatakeyama, Hitoshi, Kawano, Yoichi, Toyoda, Masashi, Korc, Murray, Ishiwata, Toshiyuki
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7602396/
https://ncbi.nlm.nih.gov/pubmed/33066597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12102976
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