Lycorine hydrochloride inhibits cell proliferation and induces apoptosis through promoting FBXW7-MCL1 axis in gastric cancer

BACKGROUND: Lycorine hydrochloride (LH), an alkaloid extracted from the bulb of the Lycoris radiata, is considered to have anti-viral, anti-malarial, and anti-tumorous effects. At present, the underlying mechanisms of LH in gastric cancer remain unclear. MCL1, an anti-apoptotic protein of BCL2 famil...

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Publicado en:J Exp Clin Cancer Res
Autores principales: Li, Chongyang, Deng, Chaowei, Pan, Guangzhao, Wang, Xue, Zhang, Kui, Dong, Zhen, Zhao, Gaichao, Tan, Mengqin, Hu, Xiaosong, Shi, Shaomin, Du, Juan, Ji, Haoyan, Wang, Xiaowen, Yang, Liqun, Cui, Hongjuan
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7602321/
https://ncbi.nlm.nih.gov/pubmed/33126914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01743-3
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