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Cytotoxicity and Mitochondrial Dysregulation Caused by α-Synuclein in Dictyostelium discoideum

Alpha synuclein has been linked to both sporadic and familial forms of Parkinson’s disease (PD) and is the most abundant protein in Lewy bodies a hallmark of Parkinson’s disease. The function of this protein and the molecular mechanisms underlying its toxicity are still unclear, but many studies hav...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cells
Hauptverfasser: Fernando, Sanjanie, Allan, Claire Y., Mroczek, Katelyn, Pearce, Xavier, Sanislav, Oana, Fisher, Paul R., Annesley, Sarah J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7602147/
https://ncbi.nlm.nih.gov/pubmed/33066427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9102289
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