IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension

PKGs are serine/threonine kinases. PKG1 has two isoforms—PKG1α and β. Inositol trisphosphate receptor (IP(3)R)-associated cGMP-kinase substrate 1 (IRAG1) is a substrate for PKG1β. IRAG1 is also known to further interact with IP(3)RI, which mediates intracellular Ca(2+) release. However, the role of...

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Publié dans:Cells
Auteurs principaux: Biswas, Siladitta, Kojonazarov, Baktybek, Hadzic, Stefan, Majer, Michael, Bajraktari, Ganimete, Novoyatleva, Tatyana, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Seeger, Werner, Weissmann, Norbert, Schlossmann, Jens, Schermuly, Ralph Theo
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7601978/
https://ncbi.nlm.nih.gov/pubmed/33066124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9102280
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