High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells

SIMPLE SUMMARY: This research investigates the disease relevance and therapeutic potential of cysteinyl leukotriene receptors in uveal melanoma (UM), a rare eye cancer that often spreads to the liver. Unfortunately, there are no therapies available to stop the spread of UM and patients are often fac...

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Publicat a:Cancers (Basel)
Autors principals: Slater, Kayleigh, Heeran, Aisling B., Garcia-Mulero, Sandra, Kalirai, Helen, Sanz-Pamplona, Rebeca, Rahman, Arman, Al-Attar, Nebras, Helmi, Mays, O’Connell, Fiona, Bosch, Rosa, Portela, Anna, Villanueva, Alberto, Gallagher, William M., Jensen, Lasse D., Piulats, Josep M., Coupland, Sarah E., O’Sullivan, Jacintha, Kennedy, Breandán N.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7600582/
https://ncbi.nlm.nih.gov/pubmed/33066024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12102950
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