Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis

BACKGROUND: Eosinophilic gastritis and duodenitis are characterized by gastrointestinal mucosal eosinophilia, chronic symptoms, impaired quality of life, and a lack of adequate treatments. Mast-cell activity may contribute to the pathogenesis of the conditions. AK002 (lirentelimab) is an anti–Siglec...

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Publicat a:N Engl J Med
Autors principals: Dellon, Evan S., Peterson, Kathryn A., Murray, Joseph A., Falk, Gary W., Gonsalves, Nirmala, Chehade, Mirna, Genta, Robert M., Leung, John, Khoury, Paneez, Klion, Amy D., Hazan, Sabine, Vaezi, Michael, Bledsoe, Adam C., Durrani, Sandy R., Wang, Chao, Shaw, Camilla, Chang, Alan T., Singh, Bhupinder, Kamboj, Amol P., Rasmussen, Henrik S., Rothenberg, Marc E., Hirano, Ikuo
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7600443/
https://ncbi.nlm.nih.gov/pubmed/33085861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2012047
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