Anti-Human PD-L1 Nanobody for Immuno-PET Imaging: Validation of a Conjugation Strategy for Clinical Translation

Immune checkpoints, such as programmed death-ligand 1 (PD-L1), limit T-cell function and tumor cells use this ligand to escape the anti-tumor immune response. Treatments with monoclonal antibodies blocking these checkpoints have shown long-lasting responses, but only in a subset of patients. This st...

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Vydáno v:Biomolecules
Hlavní autoři: Bridoux, Jessica, Broos, Katrijn, Lecocq, Quentin, Debie, Pieterjan, Martin, Charlotte, Ballet, Steven, Raes, Geert, Neyt, Sara, Vanhove, Christian, Breckpot, Karine, Devoogdt, Nick, Caveliers, Vicky, Keyaerts, Marleen, Xavier, Catarina
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7599876/
https://ncbi.nlm.nih.gov/pubmed/33003481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10101388
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