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The synergy of damage repair and retention promotes rejuvenation and prolongs healthy lifespans in cell lineages

Damaged proteins are inherited asymmetrically during cell division in the yeast Saccharomyces cerevisiae, such that most damage is retained within the mother cell. The consequence is an ageing mother and a rejuvenated daughter cell with full replicative potential. Daughters of old and damaged mother...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Schnitzer, Barbara, Borgqvist, Johannes, Cvijovic, Marija
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598927/
https://ncbi.nlm.nih.gov/pubmed/33044956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008314
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