A phase I study of pharmacokinetics of trastuzumab emtansine in Chinese patients with locally advanced inoperable or metastatic human epidermal growth factor receptor 2-positive breast cancer who have received prior trastuzumab-based therapy

BACKGROUND: Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate that retains the antitumor effects of trastuzumab while also delivering the cytotoxic antimicrotubule agent, DM1, directly to tumor cells that overexpress human epidermal growth factor receptor 2. The pharmacokinetic (PK) profil...

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Foilsithe in:Medicine (Baltimore)
Main Authors: Ji, Dongmei, Shen, Weina, Zhang, Jian, Cao, Junning, Li, Wenhua, Lam, Lisa H., Wu, Fan, Wang, Bei, Li, Zao, Sun, Guofang, Hu, Xichun, Chen, Shang-Chiung
Formáid: Artigo
Teanga:Inglês
Foilsithe: Lippincott Williams & Wilkins 2020
Ábhair:
5750
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598804/
https://ncbi.nlm.nih.gov/pubmed/33126339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MD.0000000000022886
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