BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation

Store-operated Ca(2+) entry (SOCE) is the major route of Ca(2+) influx in platelets. The Ca(2+) sensor stromal interaction molecule 1 (STIM1) triggers SOCE by forming punctate structures with the Ca(2+) channel Orai1 and the inositol trisphosphate receptor (IP(3)R), thereby linking the endo-/sarcopl...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Volz, Julia, Kusch, Charly, Beck, Sarah, Popp, Michael, Vögtle, Timo, Meub, Mara, Scheller, Inga, Heil, Hannah S., Preu, Julia, Schuhmann, Michael K., Hemmen, Katherina, Premsler, Thomas, Sickmann, Albert, Heinze, Katrin G., Stegner, David, Stoll, Guido, Braun, Attila, Sauer, Markus, Nieswandt, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598067/
https://ncbi.nlm.nih.gov/pubmed/32750041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136457
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