Complement activation on endothelium initiates antibody-mediated acute lung injury

Antibodies targeting human leukocyte antigen (HLA)/major histocompatibility complex (MHC) proteins limit successful transplantation and transfusion, and their presence in blood products can cause lethal transfusion-related acute lung injury (TRALI). It is unclear which cell types are bound by these...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Cleary, Simon J., Kwaan, Nicholas, Tian, Jennifer J., Calabrese, Daniel R., Mallavia, Beñat, Magnen, Mélia, Greenland, John R., Urisman, Anatoly, Singer, Jonathan P., Hays, Steven R., Kukreja, Jasleen, Hay, Ariel M., Howie, Heather L., Toy, Pearl, Lowell, Clifford A., Morrell, Craig N., Zimring, James C., Looney, Mark R.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598054/
https://ncbi.nlm.nih.gov/pubmed/32730229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138136
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